Chronic stress and its impact on weight loss, sleep, and immunity

16.2.2026

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Chronic stress and its impact on weight loss, sleep, and immunity

Chronic stress and long-term elevated levels of the stress hormone cortisol may contribute to the accumulation of visceral fat — especially in the abdominal area. This condition is often referred to as “cortisol belly.” Fat storage in this region may further increase the risk of metabolic disorders, diabetes, and cardiovascular problems.

What will you learn in this article?

  1. Cortisol – a good servant but a bad master
  2. 5 warning signs of chronically elevated cortisol
  3. How long-term stress relates to abdominal fat storage
  4. How cortisol is connected to vitamin D deficiency
  5. How to effectively lower cortisol levels
  6. Key takeaways


Cortisol – a good servant but a bad master

The hormone cortisol, often referred to as the “stress hormone,” is produced by the adrenal glands in response to psychological and physical pressure — helping the body react to acute threats, mobilizing energy, and increasing blood sugar levels. In situations of danger, this hormone is essential for survival, but when levels remain chronically elevated, it may negatively impact health — contributing to the accumulation of harmful abdominal fat, affecting organ health, increasing systemic inflammation, and disrupting metabolic function.

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5 warning signs of chronically elevated cortisol

Long-term elevated cortisol levels can affect overall health — from disrupting circadian rhythm and sleep quality to weakening immunity and increasing fat accumulation.

Sleep disturbances

When cortisol levels are too high — especially in the evening — the production of melatonin, the hormone essential for falling asleep and maintaining quality sleep, decreases. This may lead to difficulty falling asleep, poor sleep quality, and frequent nighttime awakenings.

Chronic inflammation

Visceral fat that accumulates as a result of stress is also a source of pro-inflammatory cytokines — signaling molecules of the immune system that trigger inflammatory responses. When their levels remain elevated long term, the body stays in a state of chronic inflammation, negatively affecting metabolism and overall health. Fat cells together with immune cells in this area release cytokines into the bloodstream, maintaining a persistent inflammatory state. This ongoing condition increases the risk of insulin resistance, type 2 diabetes, and cardiovascular diseases, and may impair metabolic and organ function.

Reduced immunity

Cortisol has a dual effect on immunity. A short-term cortisol release may have a positive effect on immune response by suppressing excessive inflammation and preventing the immune system from overreacting. Long-term elevation of cortisol levels, however, reduces the body’s immune response. Chronically elevated stress hormone levels primarily disrupt mucosal immunity in the respiratory and digestive systems and affect gut permeability. They also interfere with antibody production and reduce NK cell activity, which is crucial for antiviral defense. The result may be increased susceptibility to infections, slower healing, and more frequent relapses of viral illnesses. In some individuals, dormant viruses (e.g., herpesviruses) may even reactivate.

Metabolic disorders

Chronically elevated cortisol levels change the way the body processes glucose and responds to the hormone insulin. Over time, this may lead to insulin resistance — a condition in which cells lose the ability to respond properly to insulin and absorb glucose into tissues such as muscles. The body then increases insulin production simply to maintain normal blood sugar levels. This creates a key vicious cycle contributing to the development of type 2 diabetes and is often associated with metabolic syndrome (dyslipidemia, high blood pressure, and increased visceral fat in the abdominal area). Studies show that higher cortisol levels are linked to poorer glucose control, elevated blood sugar levels, and the presence of insulin resistance or type 2 diabetes in clinically observed populations.

Negative impact on mental wellbeing

Long-term elevated cortisol levels negatively affect nervous system function and may manifest as fatigue, mood changes, increased anxiety, and poorer recovery after both physical and psychological stress. High cortisol concentrations influence multiple brain regions involved in emotional regulation, memory, and stress adaptation. Prolonged activation of the stress response can disrupt the balance of neurotransmitters such as serotonin, dopamine, and GABA and worsen sleep quality, further contributing to fatigue and irritability.

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How to start fasting

 

How is long-term stress related to abdominal fat accumulation?

Studies suggest that higher cortisol reactivity to stress is also associated with body fat distribution — people with a higher waist-to-hip ratio tend to produce more cortisol under stress. Visceral fat is not just a cosmetic concern: its presence affects internal organ health and, due to its metabolic activity, increases the risk of inflammation, insulin resistance, and cardiovascular disease.

Abdominal fat is particularly sensitive to cortisol because it contains a higher number of glucocorticoid receptors to which this hormone binds. Cortisol promotes the formation of new fat cells in this area and facilitates energy storage while reducing fat burning. As a result, chronic stress often leads the body to store fat primarily around the waist, even when overall body weight does not change significantly.

To assess visceral fat (fat surrounding internal organs), non-invasive methods based on body measurements and composition indices are commonly used. One of the simplest is the WHR (waist-to-hip ratio) — the ratio between waist and hip circumference — where a higher ratio indicates greater visceral fat accumulation.

WHR values above 0.90 in men and 0.85 in women are associated with a higher risk of increased visceral fat.

How to start fasting
How to start fasting

 

How is cortisol related to vitamin D deficiency

Insufficient levels of vitamin D in the body may reduce the ability to regulate stress, leading to higher and more prolonged cortisol production, lower psychological resilience, and poorer sleep quality. Vitamin D influences receptor activity and signaling pathways in the brain involved in controlling cortisol secretion and other stress-related hormones. Low vitamin D status has also been associated in some studies with dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis.

Some research also suggests that vitamin D may exert anti-inflammatory effects and modulate stress-related pathways that influence both immune and endocrine responses — partly by regulating enzymes associated with cortisol and neurotransmitters linked to mood and stress.

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How to effectively lower cortisol levels

Stress management

  • Practice mindfulness, meditation, or breathing exercises — regular techniques may help reduce baseline cortisol levels.

  • Physical activity: light to moderate exercise (yoga, walking, strength training) supports hormonal balance and stress reduction.

  • Quality sleep: aim for 7–9 hours of sleep and consider a screen-free bedtime routine in a dark, cool environment.

Nutrition and dietary habits

  • Eat protein-rich foods, healthy fats, and fiber to help maintain stable blood sugar levels and support stress adaptation.

  • Limit refined sugars and ultra-processed foods, which may increase insulin levels and contribute to fat accumulation.

  • Add adaptogens (e.g., ashwagandha, rhodiola) and herbal support that may help regulate cortisol production (consult a professional before use).

Lifestyle and recovery

  • Engage in relaxation activities: meditation, yoga, warm baths, or massage.

  • Ensure sufficient rest and personal time — stress becomes problematic when it is not balanced with recovery.

  • Monitor and adjust your daily routine: consistent schedule, healthy habits, and limiting stimulating beverages (caffeine) in the evening.

  • Consider cortisol testing (e.g., saliva or blood) to determine whether levels are elevated.

  • If cortisol levels remain elevated long term, consult a physician or endocrinologist — further diagnostic evaluation (e.g., Cushing’s syndrome) may be necessary.

How to start fasting
How to start fasting


Key takeaways

  • Cortisol is an essential hormone for survival, but under chronic stress it can shift from a helpful regulator to a potential health risk.
  • Long-term elevated cortisol promotes the accumulation of visceral (abdominal) fat, often referred to as “cortisol belly.”
  • Visceral fat is metabolically active — increasing inflammation, insulin resistance, and the risk of type 2 diabetes and cardiovascular disease.
  • Abdominal fat is particularly sensitive to cortisol because it contains a higher number of stress hormone receptors.
  • Chronically high cortisol disrupts sleep, especially melatonin production.
  • Immunity weakens under prolonged stress — the body becomes more susceptible to infections and healing may slow down.
  • Cortisol influences glucose and insulin metabolism and contributes to the development of insulin resistance.
  • Psychological strain may intensify with elevated cortisol — fatigue, anxiety, and mood changes may occur.
  • Managing cortisol is not only about “mental health,” but about a combination of sleep, nutrition, movement, and daily habits.
  • Long-term care and stress-management techniques are key for hormonal balance and overall vitality.

 

Sources:

https://www.verywellmind.com/how-stress-can-cause-weight-gain-3145088

https://www.lifeextension.com/wellness/stress-anxiety/cortisol-belly

https://www.parsleyhealth.com/blog/cortisol-belly-how-to-get-rid-of-it

https://pubmed.ncbi.nlm.nih.gov/14618117/

https://pmc.ncbi.nlm.nih.gov/articles/PMC2792763/

https://www.nature.com/articles/mp2016120